Anti-Cancer Activity Screening drug discovery vitro vivo cancer screening models National Cancer Institute NCI proliferation,cancer screening drug discovery cytotoxicity, apoptosis and cell cycle analysisHollow fiber assay MTT assay, Comet assay, DNA adducts, Apoptosis (TUNEL) assay

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Anti-Cancer Activity Screening

We have access to a complete range of human and murine cancer cell lines for use in in vitro and in vivo cancer screening models. Protocols are as per National Cancer Institute (NCI), USA that can be modified as per client request.

Special competencies of our partners include:

Evaluation of the in vivo activity using various Human xenografts implants in nude athymic mice models, Carcinogen-induced lung, colon, skin, and breast tumor studies.
Evaluation of in-vitro anticancer effect including proliferation, cytotoxicity, apoptosis and cell cycle analysis & Hollow fiber assay
Diverse kind of Human cell lines include human bladder, breast, cervix, prostate, pancreas, colon, etc. Screening with wide array of cell lines maximizes chances of identifying the activity
All in vitro studies done in triplicate.
Molecular mechanism can be identified with the help of MTT assay, Comet assay, DNA adducts, Apoptosis (TUNEL) assay, Western blot analysis, Immunoprecipitation and Kinase assays.

Cell lines	Tissue of origin
T24	Human Bladder
MCF7	Human Breast
ZR-75-1	Human Breast
ME-180	Human Cervix
SiHa	Human Cervix
SK-N-SH	Human CNS
SK-N-SN	Human CNS
SNB7	Human CNS
COLO-205	Human Colon
CX-1(HT-29)	Human Colon
HT-29	Human Colon
CCRF-CEM	Human Leukemia
MOLT-4	Human Leukemia
K562	Human Leukemia
Hep-G2	Human Liver
HOP-62	Human Lung
MRI-H-165	Human Lung
SW-900	Human Lung
DWD	Human Oral
HT1080	Human Oral
A2780	Human Ovary
PA-1	Human Ovary
MIA-Pa-Ca-2	Human Pancreas
DU145	Human Prostate
PC-3	Human Prostate
G361	Human Skin
NB-EB	Neuroblastoma
Rh-1-MT	Rhabdomyosarcoma
Rh-30	Rhabdomyosarcoma

*New additions with/ without deletions in the above list of cell lines is likely

TUMOUR	HOST
L1210 Leukemia	DBA/2 mouse
P388 Leukemia	DBA/2 mouse
B-16 Melanoma	C57BL/6 mouse
Colon-26 Carcinoma	BALB/C mouse
Colon-51 Carcinoma	BALB/C mouse
Lewis Lung Carcinoma	C57BL/6 mouse
C3H mouse mammary carcinoma	C3H/Jax mouse

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